Lee S et al. (2010) J Am Soc Nephrol "Synergistic interaction between ciliary genes reflects the importance of mutational load in ciliopathies."

Weatherbee SD, Lee S

[J Am Soc Nephrol, 2010]

Schafer WR (2012) BMC Biol "Tackling thermosensation with multidimensional phenotyping."

Schafer WR

[BMC Biol, 2012]

Most if not all animals sense temperature using specialized thermosensory neurons. Genetic studies in simple organisms have been used to identify gene products required for detecting temperature changes or for mediating the effects of temperature on behaviour. A recent study has used automated imaging and multidimensional phenotyping to characterize behavioural responses to aversive temperature changes and to identify mutants with specific defects in these processes.

Peter ME et al. (1997) Cell Death Differ "Does the Caenorhabditis elegans protein CED-4 contain a region of homology to the mammalian death effector domain?"

Peter ME, Krammer PH, Medema JP

[Cell Death Differ, 1997]

The elucidatin of the apoptosis pathway in the nematode C. elegans has been helpful to understand apoptosis signaling pathways in higher eukaryotes. In the worm three genes ced-3, -4 and -9 are involved in regulating the execution of apoptosis during development. Ced-3 codes for a protease homologous to the caspase family. CED-3 activity is negatively regulated by CED-9 which is homologous both structurally and functionally to Bcl-2 and other Bcl-2 family members such as Bcl-xL. To exert its function CED-9 requires the presence of CED-4, another apoptosis promoting factor....