BAX : BAX Inhibitor

Worms co-expressing BAX inhibitotor (BI) showed healthy dopamine neurons with normal neuron morphology and continuity, similar to that of GFP control animals.

BAX : BAX Inhibitor

Worms co-expressing BAX inhibitor (BI) and BAX had a food sensing ability comparable with that of non-BAX worms, unlike worms expressing BAX alone, which exhibited no slowing in response to food.

ain-1 : ain-2 : irg-4 : sod-3

"we examined mRNA levels of a subset of these genes in ain-2[reduction-of-function (rf)];ain-1(lf) double mutants in which miRISC activity is strongly and specifically reduced (Zhang et al., 2007). We found a significant upregulation in eight of the nine AIN-2-associated, dcr-1- and pathogen-responsive genes we tested (we refer to these genes as miRISC-regulated pathogen-response [MRPR] genes hereafter) (Figure 4B). As controls, we examined the expression of ges-1 (an intestine-specific, pathogen nonresponsive gene), F08G5.6 (a pathogen-responsive gene encoding mRNAs that were not detected in the miRISC), and sod-3 (a general stressinduced gene) and found no change in the expression of these genes in ain-2(rf);ain-1(lf) double mutants."

C49G7.10 : F31F7.1 : K09D9.1 : ain-1 : ain-2 : clc-19 : clec-63 : hbl-1 : ncr-1 : tsp-1

"we examined mRNA levels of a subset of these genes in ain-2[reduction-of-function (rf)];ain-1(lf) double mutants in which miRISC activity is strongly and specifically reduced (Zhang et al., 2007). We found a significant upregulation in eight of the nine AIN-2-associated, dcr-1- and pathogen-responsive genes we tested (we refer to these genes as miRISC-regulated pathogen-response [MRPR] genes hereafter) (Figure 4B). As controls, we examined the expression of ges-1 (an intestine-specific, pathogen nonresponsive gene), F08G5.6 (a pathogen-responsive gene encoding mRNAs that were not detected in the miRISC), and sod-3 (a general stressinduced gene) and found no change in the expression of these genes in ain-2(rf);ain-1(lf) double mutants."