lin-65 : polyQ40

"We isolated 16 mutant strains that exhibited a partial or complete suppression of PolyQ-dependent hsp-6p::gfp expression in the F2 generation. The strong and stable suppression of the reporter GFP expression in a strain carrying the uth2 mutation caused us to prioritize it for additional characterization (Figure S1A)."

hsp-6 : lin-65

"We isolated 16 mutant strains that exhibited a partial or complete suppression of PolyQ-dependent hsp-6p::gfp expression in the F2 generation. The strong and stable suppression of the reporter GFP expression in a strain carrying the uth2 mutation caused us to prioritize it for additional characterization (Figure S1A)."

sams-3 : sams-4 : set-25

"The colocalization of SET-25 with H3K9me3 and its enrichment on repetitive transgene arrays prompted us to test whether SET-25 localization was dependent on H3K9 methylation. Indeed, upon depletion of sams-3/4 mCh-SET-25 distribution became diffuse, and it no longer accumulated in subnuclear foci (Figures 6B and 6C)."

pry-1 : vit-2

"We analyzed the transcript levels of vit genes in day-1 and day-4 adults and found that vit-2 was the only vitellogenin whose expression was significantly upregulated in pry-1 mutants (Figure 1A). This suggested to us that vit-2 is negatively regulated by pry-1 and may be involved in pry-1-mediated adult-specific processes."

pry-1 : vit-2

"We analyzed the transcript levels of vit genes in day-1 and day-4 adults and found that vit-2 was the only vitellogenin whose expression was significantly upregulated in pry-1 mutants (Figure 1A). This suggested to us that vit-2 is negatively regulated by pry-1 and may be involved in pry-1-mediated adult-specific processes."