Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in response to UV. Predicted to be located in cytoplasm. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; and xeroderma pigmentosum group C. Is an ortholog of human XPC (XPC complex subunit, DNA damage recognition and repair factor).
Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Involved in UV protection and transcription-coupled nucleotide-excision repair. Predicted to be located in chromatin and nucleus. Expressed in several structures, including copulatory spicule; egg-laying apparatus; neurons; oocyte; and postcloacal sensillum. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human ERCC6 (ERCC excision repair 6, chromatin remodeling factor).