vab-5

Caenorhabditis elegans

vab-6

Caenorhabditis elegans

vab-10

Caenorhabditis elegans

Predicted to enable actin filament binding activity and structural molecule activity. Involved in epidermis morphogenesis. Located in apical plasma membrane; basal plasma membrane; and hemidesmosome. Expressed in several structures, including gonad; intestinal lumen; nerve ring; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Is an ortholog of human DST (dystonin).

vab-11

Caenorhabditis elegans

vab-14

Caenorhabditis elegans

vab-12

Caenorhabditis elegans

vab-23

Caenorhabditis elegans

Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Wieacker-Wolff syndrome and female-restricted Wieacker-Wolff syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing).

vab-9

Caenorhabditis elegans

Involved in cell-cell adhesion; defense response to Gram-negative bacterium; and innate immune response. Located in cell junction. Expressed in epithelial cell; hypodermis; and nerve ring. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Is an ortholog of human TMEM47 (transmembrane protein 47).

vab-19

Caenorhabditis elegans

Involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development. Located in cell-cell junction; hemidesmosome; and intermediate filament. Expressed in hypodermis; marginal cell; uterus; and vulD. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including nephrotic syndrome type 16; palmoplantar keratoderma and woolly hair; and spastic quadriplegic cerebral palsy 2. Is an ortholog of human KANK2 (KN motif and ankyrin repeat domains 2).

vab-8

Caenorhabditis elegans

Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including egg-laying behavior; generation of neurons; and negative regulation of motor neuron migration. Located in striated muscle thin filament. Expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Is an ortholog of human KIF26A (kinesin family member 26A) and KIF26B (kinesin family member 26B).