tax-2

Caenorhabditis elegans

Contributes to intracellularly cGMP-activated cation channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; positive regulation of macromolecule biosynthetic process; and thermosensory behavior. Part of cation channel complex. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in achromatopsia 3 and retinitis pigmentosa 45. Is an ortholog of human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3).

tax-4

Caenorhabditis elegans

Enables identical protein binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Involved in several processes, including detection of stimulus; positive regulation of macromolecule biosynthetic process; and response to temperature stimulus. Located in ciliary inversin compartment; dendrite; and non-motile cilium. Part of cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 2 and retinitis pigmentosa 49. Is an ortholog of human CNGA1 (cyclic nucleotide gated channel subunit alpha 1) and CNGA2 (cyclic nucleotide gated channel subunit alpha 2).

tax-6

Caenorhabditis elegans

Enables calcium ion binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including determination of adult lifespan; male mating behavior; and response to temperature stimulus. Located in several cellular components, including neuronal cell body; nucleus; and plasma membrane bounded cell projection. Expressed in several structures, including germ line; head neurons; muscle cell; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including aortic valve stenosis; cholangiocarcinoma; and developmental and epileptic encephalopathy 91. Is an ortholog of human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma).

cnb-1

Caenorhabditis elegans

Enables calcium ion binding activity. Predicted to be involved in calcineurin-mediated signaling. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Expressed in several structures, including germ line; gonad; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Is an ortholog of human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).

gcy-8

Caenorhabditis elegans

Enables guanylate cyclase activity. Involved in microvillus organization and response to temperature stimulus. Located in microvillus membrane and neuron projection terminus. Expressed in AFDL and AFDR.

gcy-23

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in neuron projection terminus. Expressed in AFDL and AFDR.

srf-6

Caenorhabditis elegans

Used to study bacterial infectious disease.

gcy-18

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Expressed in intestine and nervous system.

unc-38

Caenorhabditis elegans

Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; neuromuscular synaptic transmission; and regulation of multicellular organismal process. Located in neuron projection and postsynaptic membrane. Expressed in several structures, including body wall musculature; copulatory spicule; enteric muscle; oblique male muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).

ttx-1

Caenorhabditis elegans

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 6 and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).