Predicted to enable NAD+ binding activity and histone deacetylase activity, NAD-dependent. Involved in innate immune response. Located in mitochondrion. Is an ortholog of human SIRT4 (sirtuin 4).
Predicted to enable electron transfer activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; carcinoma (multiple); and thrombocytopenia. Is an ortholog of human CYCS (cytochrome c, somatic).
Is affected by several genes including swsn-2.2; qui-1; and mter-4 based on RNA-seq studies. Is affected by eleven chemicals including metformin; Psoralens; and allantoin based on RNA-seq and microarray studies.
Enriched in HSN; PVD; excretory gland cell; hermaphrodite gonad; and pharyngeal cell based on single-cell RNA-seq studies. Is affected by several genes including swsn-2.2; atfs-1; and etr-1 based on RNA-seq studies.
Is affected by several genes including swsn-2.2; hsf-1; and mrps-5 based on microarray and RNA-seq studies. Is affected by five chemicals including methylmercuric chloride; paraquat; and resveratrol based on microarray and RNA-seq studies.
Is affected by several genes including swsn-2.2; hsf-1; and hsp-6 based on microarray and RNA-seq studies. Is affected by sixteen chemicals including hydrogen sulfide; Tunicamycin; and stavudine based on microarray and RNA-seq studies.
Is affected by several genes including cyc-1; swsn-2.2; and ets-4 based on microarray and RNA-seq studies. Is affected by ten chemicals including Mercuric Chloride; rotenone; and Sodium Chloride based on microarray and RNA-seq studies.
Is affected by several genes including swsn-2.2; etr-1; and hsf-1 based on RNA-seq and microarray studies. Is affected by seven chemicals including methylmercury hydroxide; multi-walled carbon nanotube; and Psoralens based on RNA-seq studies.