sel-12

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Expressed in touch receptor neurons. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).

B0379.10

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and ogt-1 based on RNA-seq studies.

C06G1.15

Caenorhabditis elegans

Is affected by adr-1; etr-1; and ogt-1 based on RNA-seq studies.

F18C5.15

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and ogt-1 based on RNA-seq studies.

F38A3.3

Caenorhabditis elegans

Is affected by cep-1; nfki-1; and ogt-1 based on RNA-seq studies.

K03C7.9

Caenorhabditis elegans

Is affected by cep-1; etr-1; and glp-1 based on RNA-seq studies.

K05D4.1

Caenorhabditis elegans

Is affected by etr-1; qui-1; and ogt-1 based on RNA-seq studies.

R05F9.14

Caenorhabditis elegans

Is affected by adr-1; etr-1; and ogt-1 based on RNA-seq studies.

R07E4.9

Caenorhabditis elegans

Is affected by cep-1; dlc-1; and etr-1 based on RNA-seq studies.

T09F3.6

Caenorhabditis elegans

Is affected by cep-1; etr-1; and ogt-1 based on RNA-seq studies.