Predicted to enable transmembrane signaling receptor activity. Involved in defense response to Gram-positive bacterium and detection of chemical stimulus. Located in cilium. Expressed in chemosensory neurons; head; tail; and uv1.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including larval locomotory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in hypodermis; nerve ring; and neurons. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 2 and hypogonadism. Is an ortholog of several human genes including ESX1 (ESX homeobox 1); PROP1 (PROP paired-like homeobox 1); and RHOXF2 (Rhox homeobox family member 2).