Enables JUN kinase kinase activity. Involved in hyperosmotic response and locomotion. Located in axon; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).
Enriched in neurons and sensory neurons based on RNA-seq studies. Is affected by several genes including fzo-1; dlc-1; and sek-1 based on RNA-seq studies. Is affected by Tunicamycin; stavudine; and Zidovudine based on RNA-seq studies.