sec-16A.1

Caenorhabditis elegans

Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein localization to endoplasmic reticulum exit site. Located in endoplasmic reticulum exit site. Is an ortholog of human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor).

sec-23

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component).

scbp-2

Caenorhabditis elegans

Predicted to be located in ribosome.

zyg-7

Caenorhabditis elegans

sec-24.1

Caenorhabditis elegans

Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Expressed widely. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human SEC24D (SEC24 homolog D, COPII coat complex component).

sec-8

Caenorhabditis elegans

Involved in vesicle tethering involved in exocytosis. Predicted to be located in growth cone membrane and synapse. Predicted to be part of exocyst. Expressed in embryonic cell; excretory canal; and hypodermis. Is an ortholog of human EXOC4 (exocyst complex component 4).

evl-7

Caenorhabditis elegans

mau-7

Caenorhabditis elegans

efsc-1

Caenorhabditis elegans

Predicted to enable translation elongation factor activity. Involved in selenocysteine incorporation. Is an ortholog of human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific).

dhcr-7

Caenorhabditis elegans

Predicted to enable 7-dehydrocholesterol reductase activity. Predicted to be involved in cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including Greenberg dysplasia; Pelger-Huet anomaly; and autoimmune disease (multiple). Is an ortholog of human DHCR7 (7-dehydrocholesterol reductase).