Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL; XXXR; and head. Human ortholog(s) of this gene implicated in artery disease (multiple); proliferative diabetic retinopathy; and type 2 diabetes mellitus. Is an ortholog of human PTPN1 (protein tyrosine phosphatase non-receptor type 1).
Predicted to enable histone H2AXY142 phosphatase activity and protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL and XXXR.
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Used to study 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).