him-8

Caenorhabditis elegans

Involved in meiotic chromosome segregation. Located in X chromosome; condensed nuclear chromosome; and nuclear envelope.

cnk-1

Caenorhabditis elegans

Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Is an ortholog of human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).

sam-10

Caenorhabditis elegans

Involved in negative regulation of gene expression; nervous system development; and regulation of protein localization to synapse. Located in nucleus. Expressed in ganglia; touch receptor neurons; and vulva. Is an ortholog of human SSBP3 (single stranded DNA binding protein 3).

Y67A10A.7

Caenorhabditis elegans

Predicted to be located in mitochondrion. Is an ortholog of several human genes including ARMCX1 (armadillo repeat containing X-linked 1); ARMCX2 (armadillo repeat containing X-linked 2); and ARMCX3 (armadillo repeat containing X-linked 3).

him-7

Caenorhabditis elegans

mtx-1

Caenorhabditis elegans

Predicted to be involved in mitochondrion organization. Predicted to be located in cytoplasm. Predicted to be part of SAM complex. Is an ortholog of human MTX3 (metaxin 3).

sam-4

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of anterograde synaptic vesicle transport; positive regulation of nematode pharyngeal pumping; and regulation of growth. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).

mau-8

Caenorhabditis elegans

Expressed in body wall musculature; germ line; hypodermis; intestine; and pharynx. Is an ortholog of human PDC (phosducin) and PDCL (phosducin like).

him-2

Caenorhabditis elegans

sdc-2

Caenorhabditis elegans

Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in X chromosome and nuclear chromosome.