mtx-1

Caenorhabditis elegans

Predicted to be involved in mitochondrion organization. Predicted to be located in cytoplasm. Predicted to be part of SAM complex. Is an ortholog of human MTX3 (metaxin 3).

ets-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of axon extension involved in regeneration and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1; germ line; head; socket cell; and sperm. Human ortholog(s) of this gene implicated in ovarian cancer. Is an ortholog of human SPDEF (SAM pointed domain containing ETS transcription factor).

aman-3

Caenorhabditis elegans

Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to be located in Golgi membrane.

sam-10

Caenorhabditis elegans

Involved in negative regulation of gene expression; nervous system development; and regulation of protein localization to synapse. Located in nucleus. Expressed in ganglia; touch receptor neurons; and vulva. Is an ortholog of human SSBP3 (single stranded DNA binding protein 3).

rpb-3

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be part of RNA polymerase II, core complex. Is an ortholog of human POLR2C (RNA polymerase II subunit C).

aptf-3

Caenorhabditis elegans

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Predicted to be located in nucleus. Expressed in head neurons and intestine.

mel-3

Caenorhabditis elegans

Acts upstream of or within embryo development.

mec-3

Caenorhabditis elegans

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including mechanosensory behavior; neuron projection organization; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Expressed in VA neuron; touch receptor neurons; ventral nerve cord; and vulva. Is an ortholog of human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5).

sam-4

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of anterograde synaptic vesicle transport; positive regulation of nematode pharyngeal pumping; and regulation of growth. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).

rpb-9

Caenorhabditis elegans

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II; transcription initiation at RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is an ortholog of human POLR2I (RNA polymerase II subunit I).