rpm-1

Caenorhabditis elegans

Enables mitogen-activated protein kinase kinase kinase binding activity; protein phosphatase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including dorsal/ventral axon guidance; negative regulation of intracellular signal transduction; and regulation of cellular component organization. Located in axon; neuromuscular junction; and presynaptic periactive zone. Part of SCF ubiquitin ligase complex. Expressed in several structures, including coelomocyte; hermaphrodite distal tip cell; nerve ring; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in colon cancer; prostate cancer; and thyroid gland carcinoma. Is an ortholog of human MYCBP2 (MYC binding protein 2).

sams-1

Caenorhabditis elegans

Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and negative regulation of lipid storage. Predicted to be located in cytosol. Expressed in body wall musculature; dorsal nerve cord; and ventral nerve cord. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Is an ortholog of human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A).

sam-10

Caenorhabditis elegans

Involved in negative regulation of gene expression; nervous system development; and regulation of protein localization to synapse. Located in nucleus. Expressed in ganglia; touch receptor neurons; and vulva. Is an ortholog of human SSBP3 (single stranded DNA binding protein 3).

sam-4

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of anterograde synaptic vesicle transport; positive regulation of nematode pharyngeal pumping; and regulation of growth. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).

K04C1.2

Caenorhabditis elegans

Enriched in several structures, including ABalaaaarl; ABalaaaarr; ABplpaaaap; PVR; and mechanosensory neurons based on microarray; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and hsf-1 based on microarray; RNA-seq; and proteomic studies. Is affected by four chemicals including Zidovudine; paraquat; and Chlorpyrifos based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Sterile alpha motif/pointed domain superfamily.

mtx-1

Caenorhabditis elegans

Predicted to be involved in mitochondrion organization. Predicted to be located in cytoplasm. Predicted to be part of SAM complex. Is an ortholog of human MTX3 (metaxin 3).

cnk-1

Caenorhabditis elegans

Predicted to be located in cytoplasm and membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Is an ortholog of human CNKSR2 (connector enhancer of kinase suppressor of Ras 2).

sahd-1

Caenorhabditis elegans

Enables dGTPase activity; deoxynucleoside triphosphate hydrolase activity; and protein homodimerization activity. Involved in dGTP catabolic process. Predicted to be located in nucleus. Expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including Aicardi-Goutieres syndrome; Chilblain lupus; and hepatitis B. Is an ortholog of human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1).

C11E4.6

Caenorhabditis elegans

Enriched in several structures, including anterior ganglion (post); dorso-rectal ganglion; head mesodermal cell; neurons; and pm8 based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; qui-1; and cua-1 based on microarray; RNA-seq; and proteomic studies. Is affected by eleven chemicals including stavudine; Zidovudine; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: PTB/PI domain; SAM domain (Sterile alpha motif); PH-like domain superfamily; Ankyrin repeats (3 copies); Ankyrin repeat; Ankyrin repeat-containing domain superfamily; Ankyrin repeat and SAM domain-containing protein 1/Caskin; Phosphotyrosine interaction domain (PTB/PID); Phosphorylation site; Sterile alpha motif/pointed domain superfamily; and Sterile alpha motif domain. Is an ortholog of human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A) and ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B). Human Anks1b enables ephrin receptor binding activity.

ave-1

Caenorhabditis elegans

Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 1. Is an ortholog of human SAMD10 (sterile alpha motif domain containing 10) and SAMD12 (sterile alpha motif domain containing 12).