- clk-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Involved in several processes, including DNA damage checkpoint signaling; determination of adult lifespan; and response to radiation. Located in cytoplasm. Expressed in several structures, including distal tip cell; gonad; head ganglion; and preanal ganglion neurons. Is an ortholog of human TELO2 (telomere maintenance 2).
- gst-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutathione transferase activity. Involved in innate immune response. Expressed in intestine and nerve ring. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).
- rad-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).
- rad-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1).
- brc-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome.
- msh-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Is an ortholog of human MSH5 (mutS homolog 5).