- xpa-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable damaged DNA binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and response to UV-C. Located in nucleus. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in xeroderma pigmentosum group A. Is an ortholog of human XPA (XPA, DNA damage recognition and repair factor).
- rad-23 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).
- rad-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1).
- gst-5 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable glutathione transferase activity. Involved in innate immune response. Expressed in intestine and nerve ring. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).
- wwp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Expressed in GABAergic neurons; cholinergic neurons; coelomocyte; somatic neurons; and vulval muscle. Is an ortholog of human WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2).
- brc-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome.