lem-3

Caenorhabditis elegans

Enables DNA endonuclease activity. Involved in several processes, including DNA metabolic process; cellular response to hydroxyurea; and response to radiation. Located in several cellular components, including condensed chromosome; midbody; and mitotic spindle midzone. Expressed in embryonic cell. Is an ortholog of human ANKLE1 (ankyrin repeat and LEM domain containing 1).

mpz-4

Caenorhabditis elegans

Predicted to be located in chromatin.

K11D12.6

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity.

gst-5

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Involved in innate immune response. Expressed in intestine and nerve ring. Is an ortholog of human HPGDS (hematopoietic prostaglandin D synthase).

rad-8

Caenorhabditis elegans

Predicted to enable NADPH dehydrogenase (quinone) activity. Involved in several processes, including defense response to other organism; positive regulation of growth rate; and response to superoxide. Located in mitochondrion. Expressed in several structures, including intestine; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in optic atrophy 10. Is an ortholog of human RTN4IP1 (reticulon 4 interacting protein 1).

rad-23

Caenorhabditis elegans

Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Expressed in dorsal nerve cord; head; neurons; ventral nerve cord; and vulva. Is an ortholog of human RAD23A (RAD23 homolog A, nucleotide excision repair protein).

rad-7

Caenorhabditis elegans

Acts upstream of or within response to UV.

Y23H5A.2

Caenorhabditis elegans

Enriched in several structures, including ABplppaapa; command interneuron; germ line; neurons; and oocyte based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; cyd-1; and cua-1 based on microarray and RNA-seq studies. Is affected by seven chemicals including rotenone; mianserin; and rifampin based on RNA-seq and microarray studies.

nhr-181

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in head neurons; intestine; neurons; and tail neurons.

C16C8.14

Caenorhabditis elegans

Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be involved in modification-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm and nucleus.