che-3

Caenorhabditis elegans

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including dauer entry; non-motile cilium assembly; and positive regulation of dauer larval development. Located in non-motile cilium. Expressed in I4 neuron; PDEL; PDER; and nerve ring. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Is an ortholog of human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1).

osm-10

Caenorhabditis elegans

Enables osmosensor activity. Involved in osmosensory signaling pathway. Located in axon; cytoplasm; and neuronal cell body.

C14A6.10

Caenorhabditis elegans

Enriched in head mesodermal cell and intestine based on RNA-seq studies. Is affected by several genes including osm-7; osm-8; and osm-11 based on microarray and RNA-seq studies. Is affected by ten chemicals including metformin; Cry5B; and quercetin based on RNA-seq and microarray studies.

osm-7

Caenorhabditis elegans

Predicted to enable Notch binding activity. Involved in regulation of gene expression and response to osmotic stress. Predicted to be located in extracellular space. Expressed in hypodermis.

F54F3.2

Caenorhabditis elegans

Is affected by several genes including osm-8; osm-11; and mrps-5 based on RNA-seq and microarray studies. Is affected by eight chemicals including stavudine; paraquat; and Heme based on RNA-seq and microarray studies.

osm-8

Caenorhabditis elegans

Involved in regulation of gene expression and response to osmotic stress. Located in extracellular space. Expressed in hyp7 syncytium.

osm-12

Caenorhabditis elegans

Involved in chemotaxis; cilium organization; and protein localization to microvillus membrane. Located in ciliary basal body; neuron projection; and non-motile cilium. Expressed in ciliated neurons and sensory neurons. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 7. Is an ortholog of human BBS7 (Bardet-Biedl syndrome 7).

osm-11

Caenorhabditis elegans

Enables Notch binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; response to osmotic stress; and vulval development. Located in apical part of cell and extracellular space. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and hermaphrodite gonad.

R10E8.2

Caenorhabditis elegans

Is affected by several genes including rsr-2; hsf-1; and osm-3 based on tiling array; RNA-seq; and microarray studies. Is predicted to encode a protein with the following domains: FTH domain and Domain of unknown function DUF38/FTH, Caenorhabditis species.

osm-6

Caenorhabditis elegans

Involved in several processes, including cellular response to salt; non-motile cilium assembly; and sensory perception of mechanical stimulus. Located in cilium; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Is an ortholog of human IFT52 (intraflagellar transport 52).