Enables enzyme binding activity and glutamate-gated receptor activity. Involved in several processes, including forward locomotion; learning or memory; and positive regulation of locomotion. Located in several cellular components, including perinuclear endoplasmic reticulum; postsynapse; and somatodendritic compartment. Part of ionotropic glutamate receptor complex. Expressed in interneuron; neurons; and ventral nerve cord. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; childhood absence epilepsy; and intellectual disability (multiple). Is an ortholog of human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).
Is affected by several genes including cyc-1; drh-3; and lpd-3 based on microarray and RNA-seq studies. Is affected by resveratrol; Chlorpyrifos; and Sirolimus based on microarray studies.
Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in intestinal cell.
Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in extracellular space and plasma membrane. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and drug dependence (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).
Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and inner mitochondrial membrane organization. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is an ortholog of human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase).
Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Expressed in intestinal cell. Is an ortholog of human ACOX3 (acyl-CoA oxidase 3, pristanoyl).
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Is an ortholog of human ALG3 (ALG3 alpha-1,3- mannosyltransferase).