Predicted to enable Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification. Located in basolateral plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CAN; anal region; intestinal muscle; tail hypodermis; and ventral nerve cord. Human ortholog(s) of this gene implicated in Zaki syndrome. Is an ortholog of human WLS (Wnt ligand secretion mediator).
Enables receptor tyrosine kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; embryonic morphogenesis; and neuron migration. Predicted to be located in extracellular space. Expressed in several structures, including HSN; P5.ppp; P7.paa; anchor cell; and epithelial cell.
Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; asymmetric protein localization involved in cell fate determination; and embryonic morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Is an ortholog of human PORCN (porcupine O-acyltransferase).
Enables mitogen-activated protein kinase kinase kinase binding activity and protein kinase activator activity. Involved in endodermal cell fate specification and negative regulation of Ras protein signal transduction. Expressed in cholinergic neurons; coelomocyte; and somatic neurons. Is an ortholog of human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1).
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including embryonic morphogenesis; neuron migration; and regulation of locomotion. Predicted to be located in plasma membrane. Expressed in several structures, including QL.a; anus; gonad; nervous system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Williams-Beuren syndrome; nonsyndromic congenital nail disorder 1; and omodysplasia 2. Is an ortholog of human FZD1 (frizzled class receptor 1); FZD2 (frizzled class receptor 2); and FZD7 (frizzled class receptor 7).
Enables MAP kinase kinase kinase activity. Involved in several processes, including cell fate commitment; embryonic digestive tract morphogenesis; and signal transduction. Located in striated muscle dense body. Expressed in BAGL and BAGR. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); frontometaphyseal dysplasia 2; and intrinsic cardiomyopathy (multiple). Is an ortholog of human MAP3K7 (mitogen-activated protein kinase kinase kinase 7).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Used to study 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. Human ortholog(s) of this gene implicated in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).
Enables protein serine/threonine kinase activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and regulation of cellular component organization. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell; seam cell; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; carcinoma (multiple); and degenerative disc disease. Is an ortholog of human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta).