Enables RNA binding activity; enzyme binding activity; and identical protein binding activity. Involved in developmental process involved in reproduction; positive regulation of gene expression; and vulval development. Located in nucleus. Expressed in anchor cell; embryonic cell; excretory cell; germ line; and somatic nervous system.
Enriched in AVK and neurons based on RNA-seq studies. Is affected by several genes including drh-3; smg-2; and mep-1 based on microarray and RNA-seq studies.
Involved in feminization of hermaphroditic germ-line and meiotic cell cycle. Located in nucleus. Expressed in germ line. Is an ortholog of human CWC25 (CWC25 spliceosome associated protein homolog).
Predicted to enable ubiquitin protein ligase activity. Involved in feminization of hermaphroditic germ-line. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Expressed in body wall musculature; germ line; intestine; pharynx; and uterus. Is an ortholog of human PPIL2 (peptidylprolyl isomerase like 2).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Sifrim-Hitz-Weiss syndrome; gastrointestinal system cancer (multiple); and lung adenocarcinoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).
Predicted to enable transcription corepressor activity. Involved in oogenesis. Located in nucleus. Is an ortholog of human CIR1 (corepressor interacting with RBPJ, CIR1).
Enables cytoskeletal protein binding activity. Involved in several processes, including locomotory behavior; myofibril assembly; and post-embryonic body morphogenesis. Located in M band and nucleus. Expressed in anal depressor muscle; body wall musculature; head muscle; and vulval muscle.