san-1

Caenorhabditis elegans

Predicted to enable protein kinase activity. Involved in mitotic spindle assembly checkpoint signaling and response to anoxia. Located in kinetochore and nucleoplasm.

such-3

Caenorhabditis elegans

such-7

Caenorhabditis elegans

such-4

Caenorhabditis elegans

mdf-1

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in embryo development; mitotic spindle assembly; and regulation of chromosome separation. Located in kinetochore; nuclear membrane; and nuclear periphery. Part of mitotic spindle assembly checkpoint MAD1-MAD2 complex. Expressed in Z1; Z2; Z3; Z4; and intestine. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Is an ortholog of human MAD1L1 (mitotic arrest deficient 1 like 1).

such-6

Caenorhabditis elegans

mdf-2

Caenorhabditis elegans

Involved in embryo development; negative regulation of metaphase/anaphase transition of cell cycle; and response to anoxia. Located in kinetochore; microtubule cytoskeleton; and nucleus. Part of mitotic spindle assembly checkpoint MAD1-MAD2 complex. Expressed in germ line. Is an ortholog of human MAD2L1 (mitotic arrest deficient 2 like 1).

such-5

Caenorhabditis elegans

such-2

Caenorhabditis elegans

fzy-1

Caenorhabditis elegans

Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in asymmetric cell division; meiotic cell cycle; and polarity specification of anterior/posterior axis. Located in condensed chromosome and cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Is an ortholog of human CDC20 (cell division cycle 20) and FZR1 (fizzy and cell division cycle 20 related 1).