Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be part of RNA polymerase II, core complex. Is an ortholog of human POLR2C (RNA polymerase II subunit C).
Enables dynein complex binding activity. Involved in several processes, including gonad development; microtubule cytoskeleton organization; and regulation of protein localization. Located in cell cortex; condensed chromosome; and spindle.
Enables sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Expressed in vulval precursor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Lewy body dementia; and schizophrenia. Is an ortholog of human ELK1 (ETS transcription factor ELK1).
Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in embryo development and transcription by RNA polymerase II. Located in nucleus. Is an ortholog of human TAF5 (TATA-box binding protein associated factor 5).
Predicted to enable 5'-nucleotidase activity. Expressed in tail. Used to study obesity. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Is an ortholog of human NT5C2 (5'-nucleotidase, cytosolic II).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; tissue development; and vulval development. Located in nucleus. Expressed in several structures, including Z2; epithelial cell; germ line; gonad; and somatic gonad precursor.
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system.