kcc-2

Caenorhabditis elegans

Enables potassium:chloride symporter activity. Involved in chloride transport; potassium ion transport; and regulation of GABAergic synaptic transmission. Predicted to be located in plasma membrane. Expressed in body wall musculature; egg-laying apparatus; hermaphrodite distal tip cell; intestine; and neurons. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; agenesis of the corpus callosum with peripheral neuropathy; and epilepsy (multiple). Is an ortholog of human SLC12A4 (solute carrier family 12 member 4); SLC12A5 (solute carrier family 12 member 5); and SLC12A7 (solute carrier family 12 member 7).

Y71H2AM.6

Caenorhabditis elegans

Predicted to enable phosphopantothenate--cysteine ligase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Is an ortholog of human PPCS (phosphopantothenoylcysteine synthetase).

gcy-27

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in chemosensory behavior and sensory perception of bitter taste. Predicted to be located in plasma membrane. Expressed in amphid neurons and head mesodermal cell. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Is an ortholog of human GUCY2C (guanylate cyclase 2C).

W07G1.1

Caenorhabditis elegans

Predicted to be involved in intracellular signal transduction. Predicted to be located in microtubule and microtubule organizing center. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; and dyslexia. Is an ortholog of human DCDC2 (doublecortin domain containing 2) and DCDC2C (doublecortin domain containing 2C).

rpi-1

Caenorhabditis elegans

Predicted to be involved in intracellular signal transduction. Located in axonemal microtubule; ciliary base; and ciliary transition zone. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; and dyslexia. Is an ortholog of human DCDC2 (doublecortin domain containing 2); DCDC2B (doublecortin domain containing 2B); and DCDC2C (doublecortin domain containing 2C).

sgn-1

Caenorhabditis elegans

Predicted to be involved in sarcomere organization. Predicted to be located in cytoskeleton and sarcolemma. Predicted to be part of sarcoglycan complex. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C; autosomal recessive limb-girdle muscular dystrophy type 2F; dilated cardiomyopathy 1L; and type 2 diabetes mellitus. Is an ortholog of human SGCD (sarcoglycan delta); SGCG (sarcoglycan gamma); and SGCZ (sarcoglycan zeta).

fem-2

Caenorhabditis elegans

Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including nematode male tail tip morphogenesis; peptidyl-threonine dephosphorylation; and sex determination. Located in protein-containing complex. Part of Cul2-RING ubiquitin ligase complex and protein serine/threonine phosphatase complex. Is an ortholog of human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F).

klp-7

Caenorhabditis elegans

Enables kinetochore binding activity. Involved in several processes, including egg-laying behavior; microtubule cytoskeleton organization; and regulation of cell cycle. Located in centrosome; kinetochore; and meiotic spindle pole. Expressed in distal tip cell; neurons; seam cell; and tail. Human ortholog(s) of this gene implicated in colorectal cancer and complex cortical dysplasia with other brain malformations 3. Is an ortholog of human KIF2A (kinesin family member 2A); KIF2B (kinesin family member 2B); and KIF2C (kinesin family member 2C).

tsen-34

Caenorhabditis elegans

Predicted to enable lyase activity; nucleic acid binding activity; and tRNA-intron endonuclease activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Is an ortholog of human TSEN34 (tRNA splicing endonuclease subunit 34).

F33G12.6

Caenorhabditis elegans

Enriched in several structures, including GLR; germ line; head ganglion; interfacial epithelial cell; and neurons based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; etr-1; and csr-1 based on microarray; tiling array; and RNA-seq studies. Is affected by six chemicals including rotenone; metformin; and Sirolimus based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: PPM-type phosphatase-like domain superfamily; PP2C-like domain-containing protein; Phosphorylation site; PPM-type phosphatase-like domain; and Protein phosphatase 2C.