Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macromolecule biosynthetic process; and response to stress. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Involved in negative regulation of turning behavior involved in mating. Predicted to be located in extracellular region. Expressed in PVM; head; nerve ring; and tail.
Predicted to enable double-stranded DNA binding activity and histone methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in chromosome.
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in intracellular calcium ion homeostasis and monoatomic cation transport. Predicted to be located in membrane. Expressed in intestine and pharynx. Is an ortholog of human SLC8B1 (solute carrier family 8 member B1).