Enables procollagen-proline 4-dioxygenase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; embryo development; and embryonic body morphogenesis. Located in endoplasmic reticulum. Expressed in hypodermis; muscle cell; neurons; and pharynx. Human ortholog(s) of this gene implicated in myopia. Is an ortholog of human P4HA1 (prolyl 4-hydroxylase subunit alpha 1) and P4HA2 (prolyl 4-hydroxylase subunit alpha 2).
Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); brain small vessel disease 2; and multiple epiphyseal dysplasia 6. Is an ortholog of human COL27A1 (collagen type XXVII alpha 1 chain); COL4A2 (collagen type IV alpha 2 chain); and COL9A1 (collagen type IX alpha 1 chain).