Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in several processes, including mitochondrial unfolded protein response; neuron migration; and positive regulation of axon guidance. Predicted to be located in plasma membrane. Expressed in anal depressor muscle; head muscle; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1 and prostate carcinoma in situ. Is an ortholog of human FZD4 (frizzled class receptor 4).
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Involved in neuroblast migration; neuron migration; and positive regulation of motor neuron migration. Predicted to be located in plasma membrane. Expressed in intestine; nervous system; and pharynx. Is an ortholog of human FZD5 (frizzled class receptor 5).
Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway. Located in Golgi apparatus; early endosome; and late endosome. Expressed in several structures, including egg-laying apparatus; enteric muscle; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); irritable bowel syndrome; and villous adenoma. Is an ortholog of human RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3).