unc-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; nervous system development; and regulation of cellular component organization. Located in axon and nucleus. Expressed in I5 neuron; cholinergic neurons; and somatic nervous system.

ceh-40

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ morphogenesis; embryonic organ development; and neuron development. Predicted to be located in nucleus. Expressed in dopaminergic neurons.

ceh-41

Caenorhabditis elegans

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in body wall musculature; neurons; and somatic nervous system.

ceh-20

Caenorhabditis elegans

Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of mesodermal cell fate specification; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P1.p; P2.p; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay; esophagus squamous cell carcinoma; and glaucoma. Is an ortholog of human PBX4 (PBX homeobox 4).

ceh-92

Caenorhabditis elegans

Predicted to enable DNA binding activity.

ceh-60

Caenorhabditis elegans

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dopaminergic neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within lipid homeostasis. Located in chromatin. Expressed in amphid neurons and sensory neurons.

ceh-21

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.

ceh-12

Caenorhabditis elegans

Predicted to enable DNA binding activity. Involved in negative regulation of gene expression and neuron fate specification. Predicted to be located in nucleus. Expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Is an ortholog of human MNX1 (motor neuron and pancreas homeobox 1).

ceh-84

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be located in nucleus.

ceh-51

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; muscle cell fate specification; and nematode pharyngeal muscle development. Located in nucleus. Expressed in several structures, including MSaa; MSap; MSp; MSpa; and MSpp.