Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Expressed in dopaminergic neurons; socket cell; and in male. Used to study several diseases, including amphetamine abuse; cocaine abuse; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; artery disease (multiple); and heroin dependence. Is an ortholog of human TH (tyrosine hydroxylase).
Is affected by ogt-1 and cat-1 based on RNA-seq studies. Is affected by five chemicals including Psoralens; allantoin; and metformin based on RNA-seq studies.
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrion. Is an ortholog of human SLC25A45 (solute carrier family 25 member 45); SLC25A47 (solute carrier family 25 member 47); and SLC25A48 (solute carrier family 25 member 48).