bli-1

Caenorhabditis elegans

Predicted to be a structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in medial layer of collagen and cuticulin-based cuticle extracellular matrix. Expressed in cuticle; hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in Stickler syndrome and multiple epiphyseal dysplasia 6. Is an ortholog of human COL27A1 (collagen type XXVII alpha 1 chain) and COL9A1 (collagen type IX alpha 1 chain).

bli-6

Caenorhabditis elegans

Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Expressed in cuticle and cuticular ala.

bli-3

Caenorhabditis elegans

Enables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic development. Located in plasma membrane. Part of oxidoreductase complex. Expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2).

let-2

Caenorhabditis elegans

An extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including embryo development; gonad morphogenesis; and regulation of distal tip cell migration. Located in basement membrane. Part of collagen type IV trimer. Expressed in several structures, including coelomocyte; egg-laying apparatus; rectal muscle; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including X-linked Alport syndrome; X-linked deafness 6; and artery disease (multiple). Is an ortholog of human COL4A1 (collagen type IV alpha 1 chain); COL4A5 (collagen type IV alpha 5 chain); and COL4A6 (collagen type IV alpha 6 chain).

cox-6B

Caenorhabditis elegans

Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Is an ortholog of human COX6B1 (cytochrome c oxidase subunit 6B1).

cox-4

Caenorhabditis elegans

Predicted to enable oxidoreductase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Is an ortholog of human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2).

let-656

Caenorhabditis elegans

let-71

Caenorhabditis elegans

let-308

Caenorhabditis elegans

cox-15

Caenorhabditis elegans

Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Predicted to be involved in heme A biosynthetic process. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Is an ortholog of human COX15 (cytochrome c oxidase assembly homolog COX15).