D2045.9

Caenorhabditis elegans

Predicted to enable procollagen galactosyltransferase activity. Human ortholog(s) of this gene implicated in brain small vessel disease 3. Is an ortholog of human COLGALT1 (collagen beta(1-O)galactosyltransferase 1) and COLGALT2 (collagen beta(1-O)galactosyltransferase 2).

icap-1

Caenorhabditis elegans

Predicted to be involved in integrin-mediated signaling pathway. Is an ortholog of human ITGB1BP1 (integrin subunit beta 1 binding protein 1).

bgal-2

Caenorhabditis elegans

Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be located in vacuole. Is an ortholog of human GLB1L (galactosidase beta 1 like).

bgal-1

Caenorhabditis elegans

Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be located in vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis type IVB. Is an ortholog of human GLB1L (galactosidase beta 1 like).

imb-1

Caenorhabditis elegans

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human KPNB1 (karyopherin subunit beta 1).

apb-1

Caenorhabditis elegans

Predicted to enable clathrin binding activity. Involved in embryo development and receptor-mediated endocytosis. Predicted to be located in cytoplasm; endomembrane system; and membrane. Predicted to be part of clathrin adaptor complex. Is an ortholog of human AP1B1 (adaptor related protein complex 1 subunit beta 1).

pbs-6

Caenorhabditis elegans

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Expressed in pharynx. Is an ortholog of human PSMB1 (proteasome 20S subunit beta 1).

chp-1

Caenorhabditis elegans

Predicted to enable zinc ion binding activity. Predicted to be involved in centrosome duplication. Is an ortholog of human CHORDC1 (cysteine and histidine rich domain containing 1) and ITGB1BP2 (integrin subunit beta 1 binding protein 2).

gba-3

Caenorhabditis elegans

Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including Gaucher's disease (multiple); Lewy body dementia; and Netherton syndrome. Is an ortholog of human GBA1 (glucosylceramidase beta 1).

tbh-1

Caenorhabditis elegans

Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Expressed in RICL; RICR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; and dopamine beta-hydroxylase deficiency. Is an ortholog of human DBH (dopamine beta-hydroxylase).