atx-3

Caenorhabditis elegans

Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail neurons. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Is an ortholog of human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like).

T22D1.5

Caenorhabditis elegans

Predicted to enable protein phosphatase regulator activity. Predicted to be part of protein phosphatase type 2A complex.

T20D3.6

Caenorhabditis elegans

Predicted to be involved in mitochondrial respirasome assembly. Located in cytoplasm. Is an ortholog of human HIGD2A (HIG1 hypoxia inducible domain family member 2A).

nspa-1

Caenorhabditis elegans

Is affected by several genes including mut-16; atx-3; and rsks-1 based on microarray and RNA-seq studies. Is affected by nine chemicals including hydrogen sulfide; methylmercuric chloride; and D-glucose based on microarray and RNA-seq studies.

F42E8.2

Caenorhabditis elegans

Is affected by several genes including cyc-1; atx-3; and osm-3 based on microarray and RNA-seq studies. Is affected by five chemicals including methylmercuric chloride; multi-walled carbon nanotube; and Acrylamide based on microarray and RNA-seq studies.

tra-2

Caenorhabditis elegans

Enables transmembrane signaling receptor activity. Involved in developmental process involved in reproduction and oocyte fate determination. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Expressed in germ line.

Y106G6E.3

Caenorhabditis elegans

Enriched in epithelial cell; hypodermis; and in male based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including cyc-1; atx-3; and hsf-1 based on microarray and RNA-seq studies. Is affected by methylmercuric chloride based on microarray studies.

Y113G7A.13

Caenorhabditis elegans

Enriched in intestine based on RNA-seq studies. Is affected by several genes including atx-3; etr-1; and srbc-48 based on microarray; RNA-seq; and proteomic studies. Is affected by five chemicals including stavudine; paraquat; and resveratrol based on RNA-seq and microarray studies.

B0464.9

Caenorhabditis elegans

Predicted to enable protein C-terminal methylesterase activity and protein phosphatase 2A binding activity. Predicted to be involved in protein demethylation. Is an ortholog of human PPME1 (protein phosphatase methylesterase 1).

B0334.10

Caenorhabditis elegans

Enriched in germ line; neurons; and in male based on RNA-seq studies. Is affected by several genes including cyc-1; cye-1; and atx-3 based on microarray and RNA-seq studies. Is affected by six chemicals including methylmercuric chloride; Doxycycline; and Chlorpyrifos based on microarray and RNA-seq studies.