arf-5

Caenorhabditis elegans

Predicted to enable GTP binding activity. Involved in embryo development and germ cell development. Predicted to be located in cytoplasm and plasma membrane. Expressed in several structures, including body wall musculature; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF5 (ARF GTPase 5).

arle-14

Caenorhabditis elegans

Predicted to be located in intracellular membrane-bounded organelle. Is an ortholog of human ARL14EP (ARF like GTPase 14 effector protein) and ARL14EPL (ARF like GTPase 14 effector protein like).

F54C8.7

Caenorhabditis elegans

Predicted to enable phospholipid binding activity. Involved in IRE1-mediated unfolded protein response. Located in mitochondrion. Is an ortholog of human ARFIP1 (ARF interacting protein 1) and ARFIP2 (ARF interacting protein 2).

Y106G6G.2

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Is an ortholog of human ARFGEF3 (ARFGEF family member 3).

agef-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in protein transport and regulation of ARF protein signal transduction. Predicted to be located in cytoplasm and membrane. Expressed in coelomocyte; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARFGEF2 (ARF guanine nucleotide exchange factor 2).

arf-1

Caenorhabditis elegans

Predicted to enable GTP binding activity. Involved in several processes, including oocyte development; regulation of apoptotic process involved in development; and regulation of receptor-mediated endocytosis. Located in endoplasmic reticulum. Expressed in head; pharyngeal muscle cell; uterus; ventral nerve cord; and vulval precursor cell. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARF1 (ARF GTPase 1) and ARF3 (ARF GTPase 3).

arl-3

Caenorhabditis elegans

Predicted to enable GTP binding activity. Predicted to be involved in cilium assembly. Predicted to be located in cytoplasm and microtubule cytoskeleton. Expressed in head neurons and tail neurons. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Is an ortholog of human ARL3 (ARF like GTPase 3).

arf-6

Caenorhabditis elegans

Predicted to enable GTP binding activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ARF GTPase 6).

arl-5

Caenorhabditis elegans

Predicted to enable GTP binding activity. Involved in microtubule cytoskeleton organization. Predicted to be located in trans-Golgi network. Is an ortholog of human ARL5A (ARF like GTPase 5A) and ARL5B (ARF like GTPase 5B).

praf-3

Caenorhabditis elegans

Predicted to be located in membrane. Is an ortholog of human ARL6IP5 (ARF like GTPase 6 interacting protein 5) and PRAF2 (PRA1 domain family member 2).