Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be involved in phospholipid biosynthetic process. Located in endoplasmic reticulum. Is an ortholog of human GPAT3 (glycerol-3-phosphate acyltransferase 3).
Predicted to enable metalloendopeptidase activity. Involved in Notch signaling pathway and cell fate specification. Predicted to be located in plasma membrane. Expressed in gonad; hypodermis; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; renal fibrosis; and type 2 diabetes mellitus. Is an ortholog of human ADAM17 (ADAM metallopeptidase domain 17).
Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is an ortholog of human CTSD (cathepsin D).
Enables carbonate dehydratase activity. Involved in small molecule metabolic process. Predicted to be located in cytoplasm. Expressed in several structures, including body wall musculature; enteric muscle; excretory cell; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and viral hepatitis. Is an ortholog of several human genes including CA1 (carbonic anhydrase 1); CA3 (carbonic anhydrase 3); and CA5A (carbonic anhydrase 5A).
Predicted to enable calcium ion binding activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Expressed in several structures, including QL; QR; VD neuron; non-striated muscle; and rectal gland cell. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Is an ortholog of human FAT1 (FAT atypical cadherin 1); FAT2 (FAT atypical cadherin 2); and FAT3 (FAT atypical cadherin 3).
Enables protein serine/threonine kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; developmental process involved in reproduction; and positive regulation of cell cycle process. Part of cyclin D1-CDK4 complex. Expressed in gonad; intestine; neurons; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human CDK4 (cyclin dependent kinase 4) and CDK6 (cyclin dependent kinase 6).
Involved in stress response to cadmium ion. Acts upstream of or within IRE1-mediated unfolded protein response. Located in lysosome. Expressed in pm5; pm6; and pm7.