Is affected by several genes including cyc-1; drh-3; and lpd-3 based on microarray and RNA-seq studies. Is affected by resveratrol; Chlorpyrifos; and Sirolimus based on microarray studies.
Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in plasma membrane. Expressed in intestinal cell.
Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in extracellular space and plasma membrane. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and drug dependence (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).
Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and inner mitochondrial membrane organization. Predicted to be located in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is an ortholog of human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase).
Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Expressed in intestinal cell. Is an ortholog of human ACOX3 (acyl-CoA oxidase 3, pristanoyl).
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Is an ortholog of human ALG3 (ALG3 alpha-1,3- mannosyltransferase).
Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Predicted to be located in cytoplasm. Is an ortholog of human ALDH1L1 (aldehyde dehydrogenase 1 family member L1) and ALDH1L2 (aldehyde dehydrogenase 1 family member L2).