sup-17

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in M lineage cell; hypodermis; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18; colorectal cancer; and reticulate acropigmentation of Kitamura. Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10).

Adam10

Rattus norvegicus

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of neuron projection development; and response to antineoplastic agent. Located in several cellular components, including postsynaptic membrane; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of several diseases, including Alzheimer's disease; cataract; status epilepticus; thoracic aortic aneurysm; and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.