Dcaf17

Homo sapiens

This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Dcaf17

Rattus norvegicus

Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within acrosome assembly and cell morphogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.