ZK930.2

Caenorhabditis elegans

Predicted to be involved in positive regulation of neuron differentiation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Wieacker-Wolff syndrome and female-restricted Wieacker-Wolff syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing).

PRKAG2-AS1

Homo sapiens

ASSOCIATED WITH hypertrophic cardiomyopathy 6; lethal congenital glycogen storage disease of heart; Wolff-Parkinson-White syndrome; INTERACTS WITH 17beta-estradiol; cadmium dichloride; carbamazepine

aakg-2

Caenorhabditis elegans

Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Is an ortholog of human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3).

vab-23

Caenorhabditis elegans

Involved in several processes, including embryonic body morphogenesis; epidermis morphogenesis; and vulval development. Located in nuclear speck. Expressed in several structures, including hermaphrodite somatic gonadal cell; ventral uterine precursor; vulval cell; vulval muscle; and vulval precursor cell. Human ortholog(s) of this gene implicated in Wieacker-Wolff syndrome and female-restricted Wieacker-Wolff syndrome. Is an ortholog of human ZC4H2 (zinc finger C4H2-type containing).

Zc4h2

Rattus norvegicus

Predicted to be involved in nervous system development and positive regulation of neuron differentiation. Predicted to act upstream of or within noradrenergic neuron development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Predicted to be located in cytoplasm; neuronal cell body; and postsynaptic membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wieacker-Wolff syndrome and female-restricted Wieacker-Wolff syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acrylamide.

aakg-1

Caenorhabditis elegans

Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Is an ortholog of human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3).

aakg-3

Caenorhabditis elegans

Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nucleotide-activated protein kinase complex. Expressed in alimentary muscle; body wall musculature; head neurons; spermatheca; and ventral nerve cord. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Is an ortholog of human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3).

Prkag2

Rattus norvegicus

Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; hypertrophic cardiomyopathy pathway; insulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; amitrole.

Prkag2

Homo sapiens

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]