- Wrnip1 [Search on AGR]
Homo sapiens Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
- Wrn [Search on AGR]
Homo sapiens This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
- wrn-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 3'-5' DNA helicase activity. Involved in DNA metabolic process; determination of adult lifespan; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Expressed in several structures, including AWCL; AWCR; and germ line. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; diffuse scleroderma; and senile cataract. Is an ortholog of human WRN (WRN RecQ like helicase).
- MGS1 [Search on AGR]
Saccharomyces cerevisiae Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
- Purg [Search on AGR]
Homo sapiens The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
- Sgs1 [Search on AGR]
Saccharomyces cerevisiae RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant
- Wrn [Search on AGR]
Rattus norvegicus Enables chromatin binding activity. Predicted to be involved in several processes, including DNA metabolic process; G-quadruplex DNA unwinding; and cellular response to gamma radiation. Predicted to act upstream of or within several processes, including determination of adult lifespan; protein localization to nucleolus; and replicative senescence. Predicted to be located in centrosome; chromosome; and nuclear lumen. Predicted to be active in chromosome; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cisplatin.