kin-18

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Involved in feeding behavior; regulation of meiosis I; and regulation of nematode pharyngeal pumping. Located in cell cortex. Expressed in several structures, including alimentary muscle; excretory cell; intestine; nerve ring; and pharyngeal-intestinal valve. Is an ortholog of human TAOK1 (TAO kinase 1); TAOK2 (TAO kinase 2); and TAOK3 (TAO kinase 3).

Tao

Drosophila melanogaster

Tao (Tao) encodes a Ser/Thr kinase belonging to the Mst/Ste20 family. It is implicated in the Hippo and PAR-1 pathways. It contributes to restriction of tissue growth during development, regulation of microtubule dynamics, neuronal polarity, neural development, ethanol-stimulated behavioral response, and apoptosis.

Schip1

Drosophila melanogaster

Schwannomin interacting protein 1 (Schip1) encodes a protein that is involved in negative regulation of organ growth by promoting the Hippo signaling pathway. It binds to the products of ex and Tao, activating the phosphorylation of the kinase encoded by hpo.

Taok2

Rattus norvegicus

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; basal dendrite arborization; and regulation of synapse organization. Is active in glutamatergic synapse and postsynapse. Orthologous to human TAOK2 (TAO kinase 2); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Taok3

Rattus norvegicus

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein autophosphorylation; and regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human TAOK3 (TAO kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Taok1

Rattus norvegicus

Enables several functions, including myosin V binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in protein phosphorylation; regulation of actin cytoskeleton organization; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including microtubule cytoskeleton; nuclear body; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TAOK1 (TAO kinase 1); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.