C47D12.2

Caenorhabditis elegans

Predicted to be involved in Golgi organization. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 1. Is an ortholog of human DYM (dymeclin).

tag-275

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

F27D9.7

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

adm-2

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); and lung disease (multiple). Is an ortholog of human ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33).

rab-33

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in Golgi apparatus and endosome. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Is an ortholog of human RAB33B (RAB33B, member RAS oncogene family).

adm-4

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in Notch signaling pathway and cell fate specification. Predicted to be located in plasma membrane. Expressed in gonad; hypodermis; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; renal fibrosis; and type 2 diabetes mellitus. Is an ortholog of human ADAM17 (ADAM metallopeptidase domain 17).

TMUE_2000010475

Trichuris muris

Is predicted to encode a protein with the following domains: ADAM, cysteine-rich domain and ADAM cysteine-rich.

RAB33B-AS1

Homo sapiens

ASSOCIATED WITH Smith-McCort dysplasia; INTERACTS WITH okadaic acid

unc-71

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23).

MTOR-AS1

Homo sapiens

ASSOCIATED WITH Focal Cortical Dysplasia of Taylor; genetic disease; Smith-Kingsmore Syndrome; INTERACTS WITH 2-hydroxypropanoic acid; rac-lactic acid