- rab-33 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in Golgi apparatus and endosome. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Is an ortholog of human RAB33B (RAB33B, member RAS oncogene family).
- Tl [Search on AGR]
Drosophila melanogaster Toll (Tl) encodes a transmembrane receptor that activates the Tl intracellular signaling pathway upon binding the ligand encoded by spz. It is involved in dorso-ventral embryonic patterning and immunity.
- tey [Search on AGR]
Drosophila melanogaster teyrha-meyrha (tey) encodes a nuclear protein that regulates neuromuscular target specificity partly by repressing the expression of Tl in specific muscles.
- MTOR-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH Focal Cortical Dysplasia of Taylor; genetic disease; Smith-Kingsmore Syndrome; INTERACTS WITH 2-hydroxypropanoic acid; rac-lactic acid
- Tehao [Search on AGR]
Drosophila melanogaster Tehao (Tehao) encodes a homologue of the receptor encoded by Tl. It is involved in the Toll signaling pathway and innate immune response.
- Slc47a1 [Search on AGR]
Homo sapiens This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
- gd [Search on AGR]
Drosophila melanogaster gastrulation-defective (gd) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis.
- Cotl1 [Search on AGR]
Homo sapiens This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]