- gd [Search on AGR]
Drosophila melanogaster gastrulation-defective (gd) encodes a secreted serine protease. It is a member of the protease cascade that generates the ligand that activates the receptor encoded by Tl. It contributes to establishment of the dorsal-ventral embryonic axis.
- Ncmap [Search on AGR]
Rattus norvegicus A structural constituent of myelin sheath. Involved in peripheral nervous system myelin formation and positive regulation of myelination. Located in Schmidt-Lanterman incisure and paranode region of axon. Orthologous to human NCMAP (non-compact myelin associated protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene.
- mal [Search on AGR]
Rattus norvegicus A structural constituent of myelin sheath. Involved in myelination. Located in Schmidt-Lanterman incisure. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human MAL (mal, T cell differentiation protein); INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- Ncmap [Search on AGR]
Homo sapiens Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be located in plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Apr 2025]
- Tnfrsf14 [Search on AGR]
Homo sapiens This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- Cldn5 [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity. Involved in myelination and response to ethanol. Located in Schmidt-Lanterman incisure; lateral plasma membrane; and paranode region of axon. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CLDN5 (claudin 5); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
- Marveld2 [Search on AGR]
Rattus norvegicus Predicted to be involved in bicellular tight junction assembly and establishment of endothelial barrier. Predicted to act upstream of or within cell-cell junction organization and sensory perception of sound. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and tight junction. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; alpha-Zearalanol.
- Jam3 [Search on AGR]
Rattus norvegicus Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and integrin binding activity. Involved in axon regeneration. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Predicted to be part of filamentous actin and protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human JAM3 (junctional adhesion molecule 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
- Sirt2 [Search on AGR]
Rattus norvegicus Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol.
- Myoc [Search on AGR]
Rattus norvegicus Predicted to enable fibronectin binding activity; myosin light chain binding activity; and signaling receptor binding activity. Involved in cellular response to nerve growth factor stimulus and nerve development. Located in Schmidt-Lanterman incisure; mesaxon; and myelin sheath abaxonal region. Biomarker of membranoproliferative glomerulonephritis and ocular hypertension. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.