tw [Search on AGR]
Drosophila melanogaster twisted (tw) encodes an endoplasmic reticulum transmembrane protein O-mannosyltransferase that, together with the rt protein, catalyzes the attachment of D-mannose to the hydroxyl group of serine or threonine in secreted or membrane proteins via an alpha-glycosidic bond. O-mannosylation of proteins such as dystroglycan Dg plays an important role in myogenesis, muscle architecture and cell adhesion.
rt [Search on AGR]
Drosophila melanogaster rotated abdomen (rt) encodes an endoplasmic reticulum transmembrane protein O-mannosyltransferase that, together with the tw protein, catalyzes the attachment of D-mannose to the hydroxyl group of serine or threonine in secreted or membrane proteins via an alpha-glycosidic bond. O-mannosylation of proteins such as dystroglycan Dg plays an important role in myogenesis, muscle architecture and cell adhesion.