salt

Drosophila melanogaster

salty dog (salt) encodes a sodium/solute symporter in the SLC5 family involved in response to salt stress.

casy-1

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Involved in several processes, including GABAergic synaptic transmission; olfactory learning; and positive regulation of synaptic vesicle transport. Located in several cellular components, including extracellular region; neuromuscular junction; and neuronal cell body membrane. Expressed in neurons. Is an ortholog of human CLSTN2 (calsyntenin 2) and CLSTN3 (calsyntenin 3).

Atp8b1

Mus musculus

PHENOTYPE: Homozygous mice display abnormal bile salt homeostasis, normal bile secretion, and an impaired ability to handle increased bile salt loading resulting in liver damage and weight loss on a bile salt supplemented diet. [provided by MGI curators]

gcy-6

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including positive regulation of calcium-mediated signaling; response to magnesium ion; and response to salt. Predicted to be located in plasma membrane. Expressed in ASEL.

gcy-5

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to salt. Located in cilium. Expressed in ASER; amphid neurons; head neurons; and nervous system.

tmc-1

Caenorhabditis elegans

Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3).

gcy-4

Caenorhabditis elegans

Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to salt. Predicted to be located in plasma membrane. Expressed in ASER.

ENA1

Saccharomyces cerevisiae

P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance

Nedd4l

Mus musculus

PHENOTYPE: Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis. [provided by MGI curators]

HAL9

Saccharomyces cerevisiae

Transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication