K10D2.8

Caenorhabditis elegans

Enriched in head mesodermal cell and in male based on RNA-seq studies. Is affected by several genes including mut-16; etr-1; and csr-1 based on microarray and RNA-seq studies. Is affected by twelve chemicals including manganese chloride; rifampin; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Leucine-rich repeat domain superfamily; Leucine Rich repeats (2 copies); SDS22/Internalin LRR-containing; Leucine-rich repeat; Leucine Rich repeat; Leucine-rich repeat, typical subtype; and Leucine rich repeat 4.

Fili

Drosophila melanogaster

Fish-lips (Fili) encodes a leucine-rich repeat family transmembrane protein. It regulates autonomous and nonautonomous apoptosis caused by the dioxin receptor homolog encoded by ss.

lrch-1

Caenorhabditis elegans

Predicted to be involved in intracellular signal transduction. Is an ortholog of several human genes including LRCH1 (leucine rich repeats and calponin homology domain containing 1); LRCH2 (leucine rich repeats and calponin homology domain containing 2); and LRCH4 (leucine rich repeats and calponin homology domain containing 4).

lron-4

Caenorhabditis elegans

Enriched in neurons based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; nuo-6; and atfs-1 based on microarray; RNA-seq; and proteomic studies. Is affected by resveratrol based on microarray studies. Is predicted to encode a protein with the following domains: Leucine rich repeat; Leucine-rich repeat domain superfamily; Leucine-rich repeat, typical subtype; and Leucine-rich repeat.

K08E7.8

Caenorhabditis elegans

Enriched in intestine; muscle cell; and somatic gonad precursor based on Chronogram; tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including etr-1; hsf-1; and srbc-48 based on RNA-seq and microarray studies. Is affected by eight chemicals including Zidovudine; rifampin; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Leucine-rich repeat domain-containing protein; Leucine rich repeat; Leucine-rich repeat domain superfamily; and Leucine-rich repeat. Is an ortholog of human LRRC20 (leucine rich repeat containing 20).

F19C7.8

Caenorhabditis elegans

Predicted to be involved in positive regulation of protein localization to plasma membrane and skeletal muscle contraction. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in Native American myopathy. Is an ortholog of human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3).

lron-15

Caenorhabditis elegans

Enriched in accessory cell; muscle cell; neurons; and uv1 based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including mter-4; etr-1; and csr-1 based on microarray and RNA-seq studies. Is affected by twelve chemicals including 1-methylnicotinamide; stavudine; and Zidovudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Multifunctional Developmental and Immune Receptor; Leucine-rich repeat domain superfamily; Leucine-rich repeat; Leucine rich repeat; and Leucine-rich repeat, typical subtype.

D2089.8

Caenorhabditis elegans

Enriched in dorsal uterine cell and germ line based on single-cell RNA-seq studies. Is affected by several genes including hsf-1; inx-14; and slr-2 based on RNA-seq and microarray studies. Is affected by four chemicals including antimycin; Hydrolyzable Tannins; and paraquat based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Cysteine-rich domain, DPF-motif; Cysteine-rich DPF motif domain-containing protein 1; and Cysteine-rich domain. Is an ortholog of human CDPF1 (cysteine rich DPF motif domain containing 1).

ZK546.2

Caenorhabditis elegans

Predicted to be located in cytoplasm. Is an ortholog of human LRRC57 (leucine rich repeat containing 57).

iglr-3

Caenorhabditis elegans

Predicted to be located in membrane. Is an ortholog of human LRRC24 (leucine rich repeat containing 24).