rhi-1

Caenorhabditis elegans

Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Located in cytosol and membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Is an ortholog of human ARHGDIA (Rho GDP dissociation inhibitor alpha); ARHGDIB (Rho GDP dissociation inhibitor beta); and ARHGDIG (Rho GDP dissociation inhibitor gamma).

rga-5

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in Rho protein signal transduction; regulation of axonogenesis; and regulation of cell size. Predicted to be located in cytosol. Is an ortholog of human ARHGAP35 (Rho GTPase activating protein 35) and ARHGAP5 (Rho GTPase activating protein 5).

tag-325

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytoplasm and plasma membrane. Is an ortholog of human ARHGAP12 (Rho GTPase activating protein 12); ARHGAP27 (Rho GTPase activating protein 27); and ARHGAP9 (Rho GTPase activating protein 9).

rga-6

Caenorhabditis elegans

Predicted to enable GTPase activator activity. Involved in defense response to fungus. Used to study long QT syndrome. Is an ortholog of human ARHGAP36 (Rho GTPase activating protein 36) and ARHGAP6 (Rho GTPase activating protein 6).

prhg-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction. Is an ortholog of human PLEKHG7 (pleckstrin homology and RhoGEF domain containing G7).

F36F2.1

Caenorhabditis elegans

Predicted to enable actin binding activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum. Is an ortholog of human ABRA (actin binding Rho activating protein).

Y92H12BL.7

Caenorhabditis elegans

Predicted to be involved in signal transduction. Is an ortholog of human ARHGAP39 (Rho GTPase activating protein 39).

rho-1

Caenorhabditis elegans

Enables several functions, including GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion. Located in cell cortex and cleavage furrow. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; multiple sclerosis; and ovarian carcinoma. Is an ortholog of human RHOA (ras homolog family member A).

rhgf-3

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Is an ortholog of human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).

ephx-1

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin cytoskeleton organization. Expressed in anchor cell; anterior distal tip cell; head; posterior distal tip cell; and uterine toroidal epithelial cell. Is an ortholog of human ARHGEF16 (Rho guanine nucleotide exchange factor 16) and ARHGEF26 (Rho guanine nucleotide exchange factor 26).