asp-12

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Involved in innate immune response. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).

asp-15

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).

asp-18

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).

asp-16

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human PGC (progastricsin) and REN (renin).

asp-19

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).

asp-5

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human REN (renin).

asp-1

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Located in cytoplasm and external side of apical plasma membrane. Expressed in intestinal cell and intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic fatigue syndrome; and congenital adrenal hyperplasia. Is an ortholog of human PGC (progastricsin) and REN (renin).

ren

Rattus norvegicus

Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cGMP; and response to lipopolysaccharide. Located in extracellular space. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction and alcohol associated liver disease; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin); PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.