Enables several functions, including BH domain binding activity; peptidase activator activity; and small molecule binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of synapse pruning; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).
Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and lipid transporter activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and phospholipid efflux. Located in plasma membrane. Expressed in Z2; Z3; germ line; neuronal sheath cell; and pharyngeal-intestinal valve.
Enables cysteine-type endopeptidase inhibitor activity and zymogen binding activity. Involved in negative regulation of apoptotic process involved in development and positive regulation of apoptotic process involved in development. Located in cytoplasm. Expressed in several structures, including germ line.
Enables GTPase activator activity and protein sequestering activity. Involved in several processes, including actin filament depolymerization; regulation of apoptotic process; and regulation of cellular component organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and perinuclear region of cytoplasm. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; B-cell lymphoma (multiple); colorectal adenocarcinoma; and transient cerebral ischemia. Is an ortholog of human BCL2L2 (BCL2 like 2) and BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough).
Enables cysteine-type endopeptidase activity; identical protein binding activity; and peptidase activator activity. Involved in several processes, including apoptotic process; regulation of apoptotic process; and regulation of developmental process. Located in several cellular components, including mitochondrion; neuronal cell body; and perinuclear region of cytoplasm. Part of caspase complex. Expressed in several structures, including ABaraapapaa; NSM; apoptotic cell; germ line; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); gastrointestinal system cancer (multiple); and prostate disease (multiple). Is an ortholog of human CASP3 (caspase 3); CASP6 (caspase 6); and CASP7 (caspase 7).
Enables protease binding activity and protein homodimerization activity. Involved in several processes, including apoptotic process; determination of adult lifespan; and mitophagy. Located in mitochondrial outer membrane and protein-containing complex. Expressed in body wall musculature; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and perinatal necrotizing enterocolitis. Is an ortholog of human BNIP3 (BCL2 interacting protein 3).
Involved in several processes, including actin filament depolymerization; apoptotic process; and positive regulation of cellular component organization. Located in cytosol; mitochondrion; and presynapse. Expressed in several structures, including ABalappaapp; ABaraapapaad; HSN; URX; and proctodeal cell.
Enables phosphatidylinositol phosphate binding activity; proline-rich region binding activity; and small GTPase binding activity. Involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and left/right axis specification. Located in cytoplasm and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Expressed in intestinal cell and tail. Is an ortholog of human ELMO1 (engulfment and cell motility 1); ELMO2 (engulfment and cell motility 2); and ELMO3 (engulfment and cell motility 3).